Optics and Photonics Society of Iran

Abstract- One of the most effective methods in studying the function of nervous system is Optogenetics. Using computational models, play a crucial role in advancing this technology. In this study, we simulate a ChR2-expressing pyramidal neuron in hippocampal area with a 19-compartment by the Hodgkin-Huxley model and ChR2 photocycle model. We found that continuous laser light into neurons, fails to control neural spikes. In fact in constant illumination, the ChR2-neuron system can reach a spiking condition with stable spiking frequency. Therefore, in this protocol we cannot control the frequency of spikes. At pulsing the light, a complex spike patterning can be attained so that, one pulse of light could induce one action potential. Results indicated that short and strong illuminations might establish better spikeso