Scleroderma is a chronic connective tissue disease accompanied with skin and inner organ fibrosis. This group of disease includes systemic sclerosis and localized scleroderma. In this article, 9 samples skin scleroderma in different thicknesses were cut by Rotary microtome device and fixed on the slides. Then, the optical properties of the samples were measured in linear absorption measurements and closed-aperture Z-Scan arrangements. The results show that the optical density (OD) of the samples varies in the range of 0.96 to 1.35 and the linear absorption decreases with age. As well as, the nonlinear refractive index of the samples was obtained from the order of 10-6(cm2/W) .