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سنتز پلیمر قالب مولکولی جهت بررسی کیفی هگزانال به عنوان یک ترکیب آلی فرار برای تشخیص سرطان ریه با استفاده از طیف سنجی رامان
Synthesis of Molecularly Imprinted Polymer for Qualitative Evaluation of Hexanal as a Volatile Organic Compound for The Diagnosis of Lung Cancer Using Raman Spectroscopy
تخصصی
Special
پژوهشي
Research
<strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">یکی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">از</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">بیماریهای</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">رایج</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">در</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">عصر</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">کنونی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">سرطان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">می‏باشدکه</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">در</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">این</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">میان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">بیشترین</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">میزان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">ابتلا</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">و مرگ</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">ومیر</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">را</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">سرطان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">ریه</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">داشته</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">است.</span></span></strong><strong><span dir="LTR"><span style="font-size:11.0pt;"> </span></span></strong><strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">تشخیص</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">به</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">موقع</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">و</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">غیرتهاجمی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">سرطان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">می‏تواند</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">به</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">پیشگیری</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">و</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">درمان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">آن</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">کمک</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">کند.</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">در</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">بازدم</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">افراد</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">مبتلا</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">به</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">سرطان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">ریه</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">ترکیبات</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">آلی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">فراری</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">موجود</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">هستند،که</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">نشانگر</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">زیستی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">مناسبی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">محسوب</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">می‏گردند</span></span></strong> <strong><span dir="LTR"><span style="font-size:11.0pt;">.</span></span></strong><strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">در</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">میان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">ترکیبات</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">آلی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">فرار</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">مختلفی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">که</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">در</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">بازدم</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">وجود</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">دار</span></span></strong><strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">ن</span></span></strong><strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">د،</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">فراوان‏ترین</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">نشانگر</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">زیستی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">هگزانال</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">است</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">که</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">در</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">افراد</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">بیمار</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">به</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">صورت</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">افزایشی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">خود</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">را</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">نشان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">می‏دهد</span></span><span dir="LTR"><span style="font-size:11.0pt;">. </span></span></strong><strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">در این پژوهش</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">با</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">سنتز</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">پلیمرقالب</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">مولکولی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">به</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">صورت</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">اختصاصی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">و</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">استفاده</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">از</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">طیف</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">سنجی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">رامان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">به</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">بررسی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">کیفی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">هگزانال</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">به</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">عنوان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">یک</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">ترکیب</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">آلی</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">فرار</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">جهت</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">کاربرد</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">در</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">تشخیص</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">سرطان</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">ریه</span></span></strong> <strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">پرداخته</span></span></strong><strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;">‏</span></span></strong><strong><span style="font-family:B Nazanin;"><span style="font-size:11.0pt;"> شده است</span></span></strong><strong><span dir="LTR"><span style="font-size:11.0pt;">.</span></span></strong><br>
<strong>One of the most common diseases in the current era is cancer, among which lung cancer has the highest incidence and mortality. Early and non-invasive diagnosis of cancer can help prevent and treat it. In exhalation of people with lung cancer, volatile organic compounds are present, which are considered good biomarkers. Among the various Volatile Organic Compounds present in exhalation, Hexanal is the most abundant biomarker that shows itself incrementally in patients. In this study, with the synthesis of Molecularly Imprinted Polymer and using Raman spectroscopy, the qualitative study of hexane as a volatile organic compound for use in the diagnosis of lung cancer has been performed.</strong><br>
پلیمر قالب مولکولی, ترکیبات عالی فرار, سرطان ریه , طیف سنجی رامان, هگزانال
Hexanal, Lung Cancer, Molecular Imprinted Polymer, Raman Spectroscopy, Volatile Organic Compound
92
95
http://opsi.ir/browse.php?a_code=A-10-1-2293&slc_lang=fa&sid=1
Abbas
Shams
عباس
شمس
10031947532846009400
10031947532846009400
Yes
Shahid Beheshti University-Laser and plasma research Institute
تهران، ولنجک، دانشگاه شهید بهشتی، پژوهشکده لیزر و پلاسما
Marziyeh
Mousazadeh
مرضیه
موسی زاده
10031947532846009401
10031947532846009401
No
Shahid Beheshti University-Laser and plasma research Institute
تهران، ولنجک، دانشگاه شهید بهشتی، پژوهشکده لیزر و پلاسما
Maryam
Nikkhah
مریم
نیکخواه
10031947532846009402
10031947532846009402
No
Shahid Beheshti University-Laser and plasma research Institute
تهران، ولنجک، دانشگاه شهید بهشتی، پژوهشکده لیزر و پلاسما
Seyed Hassan
Tavassoli
سید حسن
توسلی
10031947532846009403
10031947532846009403
No
Shahid Beheshti University-Laser and plasma research Institute
تهران، ولنجک، دانشگاه شهید بهشتی، پژوهشکده لیزر و پلاسما